HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 352
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (2-207): 1.19e-39: 148: 18.64
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Hs
		499289 KIT_HUMAN (1-976): 0: 807: 100.00		SH22A_HUMAN (17-212): 4.9e-39: 144: 29.35
+	Hs
		499282 KIT_HUMAN (1-976): 0: 807: 100.00		SHIP1_HUMAN (31-226): 5.5e-36: 140: 23.90
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (15-207): 1.82e-35: 137: 17.97
+	Hs
		275165 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP2_HUMAN (3-162): 2.51e-36: 135: 23.21
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		499266 KIT_HUMAN (1-976): 0: 807: 100.00		PTK6_HUMAN (30-149): 1.47e-32: 127: 28.46
+	Hs
		499225 KIT_HUMAN (1-976): 0: 807: 100.00		NCK1_HUMAN (1-121): 6.52e-31: 122: 28.46
+	Hs
		499280 KIT_HUMAN (1-976): 0: 807: 100.00		P55G_HUMAN (13-130): 1.15e-30: 122: 25.41
+	Hs
		499228 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG2_HUMAN (6-159): 1.15e-24: 107: 17.65
+	Hs
		499230 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG1_HUMAN (4-147): 2.82e-24: 106: 21.25
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (16-124): 2.28e-26: 106: 27.12
+	Hs
		208982 KIT_HUMAN (1-976): 0: 807: 100.00		NCK2_HUMAN (13-121): 6.71e-23: 100: 29.20
+	Mm
		292679 KIT_MOUSE (1-975): 0: 773: 79.63		GRAP2_MOUSE (3-176): 1.05e-35: 134: 21.93
+	Hs
		499246 KIT_HUMAN (1-976): 0: 807: 100.00		KSYK_HUMAN (33-142): 8.99e-18: 86.4: 27.59
+	Hs
		499245 KIT_HUMAN (1-976): 0: 807: 100.00		ZAP70_HUMAN (33-139): 9.19e-17: 83.3: 29.20