HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 261
+	Hs
		411962 KIT_HUMAN (1-976): 0: 807: 100.00		FYN_HUMAN (6-259): 1.62e-81: 255: 31.68
+	Hs
		442765 KIT_HUMAN (1-976): 0: 807: 100.00		HCK_HUMAN (7-259): 4.34e-81: 254: 30.39
+	Hs
		433539 KIT_HUMAN (1-976): 0: 807: 100.00		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		454791 KIT_HUMAN (1-976): 0: 807: 100.00		FGR_HUMAN (6-259): 4.1e-79: 249: 30.92
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (33-259): 1.87e-78: 248: 32.34
+	Hs
		411567 KIT_HUMAN (1-976): 0: 807: 100.00		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (13-259): 9.05e-77: 243: 31.37
+	Hs
		499249 KIT_HUMAN (1-976): 0: 807: 100.00		BLK_HUMAN (2-259): 4.45e-77: 243: 30.88
+	Hs
		499242 KIT_HUMAN (1-976): 0: 807: 100.00		TEC_HUMAN (7-260): 1.36e-62: 208: 21.81
+	Hs
		499243 KIT_HUMAN (1-976): 0: 807: 100.00		TXK_HUMAN (1-260): 3.18e-63: 208: 24.72
+	Hs
		337322 KIT_HUMAN (1-976): 0: 807: 100.00		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		499244 KIT_HUMAN (1-976): 0: 807: 100.00		ABL2_HUMAN (11-260): 3.92e-58: 201: 22.09
+	Hs
		499266 KIT_HUMAN (1-976): 0: 807: 100.00		PTK6_HUMAN (26-251): 9.18e-58: 192: 22.88
+	Hs
		275165 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Mm
		404012 PGFRB_MOUSE (14-974): 0: 597: 29.51		FYN_MOUSE (6-259): 1.71e-81: 255: 31.68
+	Mm
		292679 KIT_MOUSE (1-975): 0: 773: 79.63		GRAP2_MOUSE (37-176): 1.25e-13: 71.2: 35.71
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (37-176): 3.68e-13: 68.6: 32.39
+	Hs
		337317 PGFRB_HUMAN (30-954): 0: 591: 30.62		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Mm
		404013 PGFRB_MOUSE (14-974): 0: 597: 29.51		GRB2_MOUSE (37-176): 3.68e-13: 68.6: 32.39