HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0030032 - lamellipodium assembly GO:0046872 - metal ion binding GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 847
+	Mm
		403536 KIT_MOUSE (1-975): 0: 773: 79.63		VAV_MOUSE (1-846): 0: 600: 57.90
+	Hs
		452495 PGFRB_HUMAN (30-954): 0: 591: 30.62		VAV3_HUMAN (1-847): 0: 663: 100.00
+	Hs
		452342 PGFRB_HUMAN (30-954): 0: 591: 30.62		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		452375 PGFRB_HUMAN (30-954): 0: 591: 30.62		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (613-844): 1.55e-21: 95.9: 27.47
+	Hs
		499228 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		499230 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		452448 PGFRB_HUMAN (30-954): 0: 591: 30.62		FGD6_HUMAN (86-611): 2.71e-73: 264: 15.69
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		452348 PGFRB_HUMAN (30-954): 0: 591: 30.62		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Mm
		404013 PGFRB_MOUSE (14-974): 0: 597: 29.51		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		452385 PGFRB_HUMAN (30-954): 0: 591: 30.62		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		738192 FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Dm
		112228 M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32		VAV_DROME (2-601): 7.73e-119: 380: 30.06
+	Hs
		580923 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		580927 FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		601492 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		609244 FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Dm
		112214 M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32		GRAP_DROME (672-843): 3.76e-15: 77: 31.25