HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: SH2B3 (Q9UQQ2)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	18588518, 24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0035162 - embryonic hemopoiesis GO:0035556 - intracellular signal transduction GO:0035855 - megakaryocyte development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 575
+	Hs
		499291 KIT_HUMAN (1-976): 0: 807: 100.00		VAV3_HUMAN (197-544): 5.15e-53: 196: 13.43
+	Hs
		499222 KIT_HUMAN (1-976): 0: 807: 100.00		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Hs
		433226 KIT_HUMAN (1-976): 0: 807: 100.00		YES_HUMAN (229-557): 2.62e-45: 169: 13.20
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (303-544): 2.13e-46: 164: 12.81
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Hs
		499248 KIT_HUMAN (1-976): 0: 807: 100.00		CRKL_HUMAN (364-541): 1.25e-41: 154: 22.35
+	Hs
		499225 KIT_HUMAN (1-976): 0: 807: 100.00		NCK1_HUMAN (286-446): 2.61e-38: 147: 18.39
+	Hs
		499279 KIT_HUMAN (1-976): 0: 807: 100.00		SHC3_HUMAN (290-466): 4.39e-37: 147: 22.60
+	Hs
		208982 KIT_HUMAN (1-976): 0: 807: 100.00		NCK2_HUMAN (237-453): 3.16e-38: 146: 16.07
+	Mm
		403536 KIT_MOUSE (1-975): 0: 773: 79.63		VAV_MOUSE (192-573): 4.75e-44: 169: 11.00
+	Hs
		499256 KIT_HUMAN (1-976): 0: 807: 100.00		SHC2_HUMAN (290-469): 3.78e-31: 129: 24.47
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (307-547): 1.13e-45: 162: 12.45
+	Hs
		499237 KIT_HUMAN (1-976): 0: 807: 100.00		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Hs
		499246 KIT_HUMAN (1-976): 0: 807: 100.00		KSYK_HUMAN (363-573): 4.78e-25: 111: 15.57
+	Hs
		499274 KIT_HUMAN (1-976): 0: 807: 100.00		SHC4_HUMAN (307-468): 2.5e-24: 109: 24.26
+	Hs
		499241 KIT_HUMAN (1-976): 0: 807: 100.00		MATK_HUMAN (343-444): 6e-22: 101: 32.35
+	Hs
		499230 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Hs
		129178 KIT_HUMAN (1-976): 0: 807: 100.00		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38
+	Mm
		403538 KIT_MOUSE (1-975): 0: 773: 79.63		MATK_MOUSE (340-444): 1.69e-21: 100: 31.53
+	Mm
		140055 KIT_MOUSE (1-975): 0: 773: 79.63		P85B_MOUSE (329-473): 6.89e-20: 95.9: 18.49