HitPredict

Interactor 1: CD28 (P10747)
T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)
Gene: CD28

Interactor 2: CD80 (P33681)
T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
Gene: CD80

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

The method score is based on:

Property	Details
Experiments	1847722, 7545666, 21982860, 7964482, 2164219
Identification Methods	pull down, coimmunoprecipitation, experimental interaction detection, protein array
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	V-set~V-set_2
Common GO terms	GO:0005886 - plasma membrane GO:0007166 - cell surface receptor signaling pathway GO:0009897 - external side of plasma membrane GO:0009986 - cell surface GO:0015026 - coreceptor activity and 5 others more... GO:0031295 - T cell costimulation GO:0032743 - positive regulation of interleukin-2 production GO:0042102 - positive regulation of T cell proliferation GO:0042110 - T cell activation GO:0098636 - protein complex involved in cell adhesion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	220
Hs

1	288

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024