HitPredict

Interactor 1: CD28 (P10747)
T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)
Gene: CD28

Interactor 2: CD86 (P42081)
T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
Gene: CD86

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

The method score is based on:

Property	Details
Experiments	21931534, 27708164
Identification Methods	surface plasmon resonance, fluorescence-activated cell sorting
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	V-set~V-set_2
Common GO terms	GO:0005886 - plasma membrane GO:0007166 - cell surface receptor signaling pathway GO:0009897 - external side of plasma membrane GO:0009986 - cell surface GO:0015026 - coreceptor activity and 5 others more... GO:0031295 - T cell costimulation GO:0032743 - positive regulation of interleukin-2 production GO:0032753 - positive regulation of interleukin-4 production GO:0042102 - positive regulation of T cell proliferation GO:0042110 - T cell activation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	220
Hs

1	329

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024