Interactor 1: IL1B (P10749)
Interleukin-1 beta (IL-1 beta)
Gene: IL1B

Interactor 2: IL1R1 (P13504)
Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
Gene: IL1R1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.33 1.00 0.575

The method score is based on:

Property Details
Experiments 17675517
Identification Methods enzyme linked immunosorbent assay
Interaction Type association

The annotation score is based on:

Property Details
Interacting Pfam domains IL1~I-set, IL1~Ig_2
Common GO terms GO:0005615 - extracellular space
GO:0006954 - inflammatory response
GO:0019221 - cytokine-mediated signaling pathway
GO:0032729 - positive regulation of type II interferon production
GO:0070498 - interleukin-1-mediated signaling pathway
and 1 others

more...

Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 269
Mm

1 576
+ Hs
+ Mm
+ Mm
+ Hs
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+ Hs
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+ Hs
+ Hs

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Last updated: 15 Jul 2024