HitPredict

Interactor 1: CD14 (P10810)
Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14)
Gene: CD14

Interactor 2: TLR7 (P58681)
Toll-like receptor 7
Gene: TLR7

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21078886
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_1~LRR_1, LRR_1~LRR_8
Common GO terms	GO:0006954 - inflammatory response GO:0032729 - positive regulation of type II interferon production GO:0032757 - positive regulation of interleukin-8 production GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 366 Mm			1 1050
+	Hs
		441038 CD14_HUMAN (13-365): 1.58e-91: 280: 65.56		TLR7_HUMAN (1-1050): 3.95e-152: 481: 80.76
+	Hs
		441036 CD14_HUMAN (13-365): 1.58e-91: 280: 65.56		TLR8_HUMAN (14-1050): 9.69e-139: 445: 41.43
+	Hs
		441035 CD14_HUMAN (13-365): 1.58e-91: 280: 65.56		TLR9_HUMAN (2-1049): 7.32e-134: 432: 34.47
+	Mm
		500268 CD14_MOUSE (1-366): 1.73e-91: 280: 100.00		TLR9_MOUSE (10-1049): 6.47e-122: 400: 34.96
+	Mm
		500267 CD14_MOUSE (1-366): 1.73e-91: 280: 100.00		TLR3_MOUSE (12-490): 2.08e-26: 118: 18.60
+	Hs
		179922 CD14_HUMAN (13-365): 1.58e-91: 280: 65.56		TLR3_HUMAN (444-897): 9.27e-26: 116: 17.25
+	Hs
		237458 CD14_HUMAN (13-365): 1.58e-91: 280: 65.56		TLR2_HUMAN (8-555): 1.43e-23: 109: 14.51
+	Mm
		500265 CD14_MOUSE (1-366): 1.73e-91: 280: 100.00		TLR8_MOUSE (435-784): 4.83e-20: 98.4: 18.80
+	Zm
		19443 A0A1D6HD42_MAIZE (57-362): 3.97e-37: 144: 20.58		A0A1D6HD42_MAIZE (149-711): 3.4e-62: 232: 18.59
+	Hs
		120124 CD14_HUMAN (13-365): 1.58e-91: 280: 65.56		TLR4_HUMAN (657-916): 4.99e-12: 72.3: 14.56
+	Mm
		500270 CD14_MOUSE (1-366): 1.73e-91: 280: 100.00		TLR4_MOUSE (657-813): 3.15e-11: 69.8: 22.29
+	Hs
		237517 TLR10_HUMAN (55-336): 7.4e-68: 230: 20.00		TLR2_HUMAN (8-555): 1.43e-23: 109: 14.51
+	Hs
		1315638 TLR10_HUMAN (55-336): 7.4e-68: 230: 20.00		TLR10_HUMAN (43-584): 1.38e-21: 103: 16.31
+	Hs
		1073332 TLR10_HUMAN (55-336): 7.4e-68: 230: 20.00		TLR1_HUMAN (656-782): 2.02e-09: 63.7: 21.26
+	Hs
		1315642 TLR10_HUMAN (55-336): 7.4e-68: 230: 20.00		TLR6_HUMAN (128-453): 4.34e-09: 62.5: 14.63
+	At
		83970 O64794_ARATH (160-348): 9.42e-24: 104: 19.90		Y1743_ARATH (1-369): 9.23e-41: 165: 14.39
+	At
		1321287 Y1668_ARATH (11-246): 5.31e-24: 105: 15.19		BRL1_ARATH (6-385): 1.18e-38: 158: 17.11
+	At
		1321273 Y1668_ARATH (11-246): 5.31e-24: 105: 15.19		FLS2_ARATH (1-269): 2.75e-27: 122: 14.78
+	At
		1325025 PXL1_ARATH (60-333): 9.95e-27: 113: 18.55		BRL3_ARATH (629-921): 2.58e-16: 86.5: 15.05
+	At
		1321277 Y1668_ARATH (11-246): 5.31e-24: 105: 15.19		BRL3_ARATH (629-921): 2.58e-16: 86.5: 15.05