HitPredict

Interactor 1: RARB (P10826)
Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon)
Gene: RARB

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	15604093, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 455 Hs			1 406
+	Hs
		487934 RARA_HUMAN (1-424): 2.91e-138: 406: 82.12		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		587150 RXRA_HUMAN (2-417): 2.57e-131: 389: 30.05		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		530791 RARG_HUMAN (1-451): 3.68e-129: 383: 71.74		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369311 ESR1_HUMAN (12-450): 5.73e-119: 361: 22.43		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		500475 THB_HUMAN (47-416): 8.05e-120: 359: 35.10		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		906980 ERR3_HUMAN (13-417): 2.34e-118: 355: 29.06		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Rn
		411261 ESR1_RAT (12-451): 3.54e-114: 349: 22.59		PRS8_RAT (1-406): 1.42e-136: 398: 100.00
+	Hs
		369310 ESR1_HUMAN (12-450): 5.73e-119: 361: 22.43		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		611412 NR4A1_HUMAN (9-417): 2.2e-109: 337: 30.10		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907027 HNF4G_HUMAN (77-421): 5.98e-112: 337: 26.67		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907111 ESR2_HUMAN (1-451): 2.3e-108: 332: 24.03		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907008 NR1H3_HUMAN (12-418): 9.97e-107: 325: 28.84		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369145 ESR1_HUMAN (12-450): 5.73e-119: 361: 22.43		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		611411 NR4A1_HUMAN (9-417): 2.2e-109: 337: 30.10		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		906889 ESR2_HUMAN (1-451): 2.3e-108: 332: 24.03		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		369100 ESR1_HUMAN (12-450): 5.73e-119: 361: 22.43		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		798727 ESR2_HUMAN (1-451): 2.3e-108: 332: 24.03		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		730322 ESR2_HUMAN (1-451): 2.3e-108: 332: 24.03		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		369327 ESR1_HUMAN (12-450): 5.73e-119: 361: 22.43		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	Hs
		913328 ESR2_HUMAN (1-451): 2.3e-108: 332: 24.03		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64