HitPredict

Interactor 1: THA (P10827)
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
Gene: THRA

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9440806
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 526
+	Hs
		370139 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		587128 RXRA_HUMAN (6-409): 6.39e-113: 343: 24.69		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		369097 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		369431 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		370711 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Mm
		509294 RARA_MOUSE (9-406): 6.8e-104: 319: 31.33		FUS_MOUSE (1-526): 6.91e-34: 136: 86.72
+	Hs
		510005 ERR1_HUMAN (49-352): 1.25e-97: 302: 29.93		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Mm
		509319 RARA_MOUSE (9-406): 6.8e-104: 319: 31.33		EWS_MOUSE (3-451): 2.8e-30: 127: 35.56
+	Hs
		370820 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Mm
		1142642 ERR2_MOUSE (1-409): 3.66e-101: 312: 21.41		EWS_MOUSE (3-451): 2.8e-30: 127: 35.56
+	Hs
		369739 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		PAP1L_HUMAN (182-382): 2.39e-13: 74.7: 13.43
+	Hs
		369534 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		368886 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		370422 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		PABP3_HUMAN (275-379): 5.23e-10: 63.9: 19.05
+	Hs
		782537 HNF4A_HUMAN (8-451): 1.23e-104: 322: 21.87		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Mm
		509289 RARA_MOUSE (9-406): 6.8e-104: 319: 31.33		PABP1_MOUSE (184-382): 3.6e-12: 70.8: 12.44
+	Hs
		611479 NR4A1_HUMAN (52-342): 2.7e-32: 132: 31.62		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		611434 NR4A1_HUMAN (52-342): 2.7e-32: 132: 31.62		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		516359 NR4A1_HUMAN (52-342): 2.7e-32: 132: 31.62		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44