HitPredict

Interactor 1: THA (P10827)
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
Gene: THRA

Interactor 2: IMA5 (P52294)
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Gene: KPNA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31319097
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arm~Hormone_recep
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 538
+	Hs
		500471 THB_HUMAN (40-404): 8.75e-113: 342: 74.66		IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00
+	Hs
		369225 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00
+	Hs
		134821 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		IMA3_HUMAN (1-538): 7e-156: 456: 45.84
+	Hs
		131362 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		IMA4_HUMAN (3-538): 1.73e-150: 443: 45.91
+	Hs
		369224 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		IMA1_HUMAN (3-538): 1.64e-149: 441: 44.36
+	Hs
		238631 NR4A1_HUMAN (52-342): 2.7e-32: 132: 31.62		IMA7_HUMAN (1-538): 6.51e-160: 467: 80.48
+	Hs
		611404 NR4A1_HUMAN (52-342): 2.7e-32: 132: 31.62		IMA5_HUMAN (1-538): 9.01e-156: 457: 100.00