HitPredict

Interactor 1: THA (P10827)
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
Gene: THRA

Interactor 2: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	10681503, 10567404, 10847592, 10866662
Identification Methods	pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 490 Hs			1 2063
+	Hs
		587169 RXRA_HUMAN (6-409): 6.39e-113: 343: 24.69		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		500485 THB_HUMAN (40-404): 8.75e-113: 342: 74.66		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		369612 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		500454 THA_HUMAN (1-490): 1.27e-155: 453: 100.00		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Mm
		99860 THA_MOUSE (1-490): 3.06e-152: 444: 95.73		F6M2J9_MOUSE (339-1212): 9.08e-12: 72.9: 10.93
+	Hs
		370417 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		TARA_HUMAN (168-1726): 1.14e-25: 118: 9.69
+	Hs
		500380 RARB_HUMAN (5-454): 1.19e-116: 352: 29.93		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		368927 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		MUC1_HUMAN (159-883): 4.81e-23: 110: 10.47
+	Hs
		587211 RXRA_HUMAN (6-409): 6.39e-113: 343: 24.69		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		500510 THB_HUMAN (40-404): 8.75e-113: 342: 74.66		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		818890 RXRG_HUMAN (9-410): 4.46e-112: 341: 24.07		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		370824 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		369171 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Mm
		99859 THB_MOUSE (13-404): 6.61e-113: 342: 69.80		F6M2J9_MOUSE (339-1212): 9.08e-12: 72.9: 10.93
+	Hs
		369607 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Mm
		57184 THB_MOUSE (13-404): 6.61e-113: 342: 69.80		CHD7_MOUSE (154-620): 1.03e-10: 69.8: 13.63
+	Hs
		370607 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		CHD7_HUMAN (169-662): 2.63e-11: 71.8: 12.93
+	Hs
		370040 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23
+	Hs
		370263 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		MINT_HUMAN (1100-2062): 1.16e-09: 66.2: 9.24
+	Hs
		370728 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		SRRM2_HUMAN (1328-2061): 5.87e-09: 63.7: 10.47