HitPredict

Interactor 1: THA (P10827)
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
Gene: THRA

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	8710870, 10198638
Identification Methods	biochemical, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 490 Hs			1 2177
+	Hs
		370154 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		MED12_HUMAN (1-2177): 0: 2488: 100.00
+	Hs
		500421 THA_HUMAN (1-490): 1.27e-155: 453: 100.00		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Mm
		99860 THA_MOUSE (1-490): 3.06e-152: 444: 95.73		F6M2J9_MOUSE (1841-2175): 8.77e-09: 63: 13.27
+	Hs
		370329 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		DIDO1_HUMAN (1479-2099): 1.5e-18: 95.4: 10.74
+	Mm
		581219 THB_MOUSE (13-404): 6.61e-113: 342: 69.80		NFH_MOUSE (1680-2143): 1.23e-14: 82.3: 8.63
+	Hs
		370040 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		KMT2C_HUMAN (1619-2174): 8.59e-16: 86.5: 10.80
+	Hs
		587190 RXRA_HUMAN (6-409): 6.39e-113: 343: 24.69		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Mm
		57184 THB_MOUSE (13-404): 6.61e-113: 342: 69.80		CHD7_MOUSE (1920-2177): 3.13e-11: 71.5: 13.60
+	Hs
		369869 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		CRACD_HUMAN (1744-2168): 6.51e-13: 76.8: 16.78
+	Mm
		70903 THB_MOUSE (13-404): 6.61e-113: 342: 69.80		EP300_MOUSE (1845-2169): 2.28e-10: 68.7: 22.10
+	Hs
		587169 RXRA_HUMAN (6-409): 6.39e-113: 343: 24.69		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Hs
		500485 THB_HUMAN (40-404): 8.75e-113: 342: 74.66		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Mm
		70894 RARB_MOUSE (11-454): 2.59e-111: 339: 30.49		EP300_MOUSE (1845-2169): 2.28e-10: 68.7: 22.10
+	Hs
		370136 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		370286 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Mm
		101427 RXRG_MOUSE (9-410): 2.51e-111: 339: 24.07		F8VPR5_MOUSE (1658-2031): 7.3e-10: 66.9: 11.66
+	Mm
		99859 THB_MOUSE (13-404): 6.61e-113: 342: 69.80		F6M2J9_MOUSE (1841-2175): 8.77e-09: 63: 13.27
+	Hs
		370607 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		CHD7_HUMAN (1825-2174): 2.18e-10: 68.8: 10.05
+	Hs
		369612 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Hs
		370225 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		EP400_HUMAN (1812-2174): 7.89e-09: 63.4: 17.63