HitPredict

Interactor 1: THB (P10828)
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Gene: THRB

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 461 Hs			1 375
+	Hs
		500492 THB_HUMAN (1-461): 1.52e-149: 435: 100.00		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		369847 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		POTEE_HUMAN (1-375): 0: 736: 92.00
+	Hs
		369745 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		500476 THB_HUMAN (1-461): 1.52e-149: 435: 100.00		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Mm
		740734 THB_MOUSE (1-461): 4.36e-149: 434: 96.53		ACTA_MOUSE (2-375): 0: 591: 94.12
+	Hs
		369279 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Mm
		509295 RARA_MOUSE (26-461): 1.67e-111: 338: 30.23		ACTB_MOUSE (1-375): 0: 603: 100.00
+	Hs
		369366 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Mm
		521437 NR4A1_MOUSE (5-461): 1.99e-102: 319: 25.43		ACTB_MOUSE (1-375): 0: 603: 100.00