HitPredict

Interactor 1: THB (P10828)
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Gene: THRB

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	9368056, 15604093, 7870181
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 461 Hs			1 406
+	Hs
		587150 RXRA_HUMAN (19-460): 4.47e-117: 352: 22.49		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		500362 RARB_HUMAN (29-461): 2.45e-115: 347: 32.05		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369311 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		906997 PPARD_HUMAN (87-461): 8.06e-112: 338: 28.46		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		487934 RARA_HUMAN (30-461): 2.47e-111: 337: 30.46		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Rn
		411261 ESR1_RAT (10-460): 2.37e-108: 334: 18.74		PRS8_RAT (1-406): 1.42e-136: 398: 100.00
+	Hs
		611412 NR4A1_HUMAN (5-461): 3.03e-108: 334: 25.86		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907008 NR1H3_HUMAN (11-460): 4.58e-110: 334: 26.97		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		906980 ERR3_HUMAN (41-460): 1.59e-107: 328: 25.24		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		530791 RARG_HUMAN (31-461): 3.61e-107: 327: 30.51		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369310 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		611411 NR4A1_HUMAN (5-461): 3.03e-108: 334: 25.86		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		907027 HNF4G_HUMAN (98-459): 2.45e-104: 318: 24.86		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369145 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		740491 PPARG_HUMAN (28-461): 2.21e-100: 311: 24.33		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		369100 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		907028 NR1I3_HUMAN (103-443): 1.11e-46: 166: 32.86		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		265859 NR1I2_HUMAN (105-459): 5.25e-43: 159: 29.18		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		798664 NR1I3_HUMAN (103-443): 1.11e-46: 166: 32.86		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		369327 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64