HitPredict

Interactor 1: THB (P10828)
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Gene: THRB

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 461 Hs			1 377
+	Hs
		500492 THB_HUMAN (1-461): 1.52e-149: 435: 100.00		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		369745 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		500473 THB_HUMAN (1-461): 1.52e-149: 435: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Mm
		740734 THB_MOUSE (1-461): 4.36e-149: 434: 96.53		ACTA_MOUSE (1-377): 0: 596: 100.00
+	Hs
		369279 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		369366 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Mm
		509295 RARA_MOUSE (26-461): 1.67e-111: 338: 30.23		ACTB_MOUSE (4-377): 0: 598: 94.12
+	Mm
		521437 NR4A1_MOUSE (5-461): 1.99e-102: 319: 25.43		ACTB_MOUSE (4-377): 0: 598: 94.12