HitPredict

Interactor 1: THB (P10828)
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Gene: THRB

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	15604093, 9346901, 20956942
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 461 Hs			1 1424
+	Hs
		587212 RXRA_HUMAN (19-460): 4.47e-117: 352: 22.49		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		500381 RARB_HUMAN (29-461): 2.45e-115: 347: 32.05		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		370839 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		500487 THB_HUMAN (1-461): 1.52e-149: 435: 100.00		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		587195 RXRA_HUMAN (19-460): 4.47e-117: 352: 22.49		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Hs
		369703 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		500491 THB_HUMAN (1-461): 1.52e-149: 435: 100.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		587173 RXRA_HUMAN (19-460): 4.47e-117: 352: 22.49		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126103 RXRA_HUMAN (19-460): 4.47e-117: 352: 22.49		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		369673 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		975430 PPARD_HUMAN (87-461): 8.06e-112: 338: 28.46		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		370292 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		EPAS1_HUMAN (12-878): 3.88e-100: 343: 13.27
+	Hs
		181498 RXRA_HUMAN (19-460): 4.47e-117: 352: 22.49		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		587177 RXRA_HUMAN (19-460): 4.47e-117: 352: 22.49		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		500364 RARB_HUMAN (29-461): 2.45e-115: 347: 32.05		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		369684 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		369025 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Mm
		936666 NR1H3_MOUSE (11-460): 3.28e-112: 339: 26.65		NCOA1_MOUSE (1-1353): 1.77e-74: 275: 23.72
+	Hs
		369099 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		AHR_HUMAN (12-793): 4.1e-70: 255: 12.66
+	Hs
		370040 ESR1_HUMAN (8-460): 1.87e-111: 342: 18.66		KMT2C_HUMAN (471-1383): 2.87e-11: 70.9: 12.87