HitPredict

Interactor 1: CCL3 (P10855)
C-C motif chemokine 3 (Heparin-binding chemotaxis protein) (L2G25B) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (SIS-alpha) (Small-inducible cytokine A3) (TY-5)
Gene: CCL3

Interactor 2: CCR1 (P51675)
C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
Gene: CCR1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9139699
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0005737 - cytoplasm GO:0006954 - inflammatory response GO:0007204 - positive regulation of cytosolic calcium ion concentration GO:0019722 - calcium-mediated signaling GO:0030595 - leukocyte chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 92 Mm			1 355
+	Mm
		500591 CCL3_MOUSE (1-92): 2.57e-39: 127: 100.00		CCR3_MOUSE (13-355): 3.59e-87: 268: 62.68
+	Hs
		561728 CL3L1_HUMAN (1-92): 1.09e-36: 120: 74.19		CCR1_HUMAN (1-355): 1.1e-88: 272: 80.00
+	Hs
		526560 CCL4_HUMAN (1-91): 1.49e-35: 117: 60.87		CCR1_HUMAN (1-355): 1.1e-88: 272: 80.00
+	Hs
		686667 CCL14_HUMAN (1-91): 1.84e-34: 115: 45.16		CCR1_HUMAN (1-355): 1.1e-88: 272: 80.00
+	Hs
		486230 CCL3_HUMAN (1-92): 1.09e-33: 113: 74.19		CCR1_HUMAN (1-355): 1.1e-88: 272: 80.00
+	Hs
		1305163 CCL13_HUMAN (1-92): 3.42e-36: 119: 43.01		ACKR4_HUMAN (6-343): 1.47e-81: 254: 30.81
+	Hs
		783833 CCL13_HUMAN (1-92): 3.42e-36: 119: 43.01		CCR2_HUMAN (8-344): 1.3e-75: 239: 49.41
+	Hs
		561732 CL3L1_HUMAN (1-92): 1.09e-36: 120: 74.19		CCR3_HUMAN (1-355): 3.49e-72: 230: 58.03
+	Hs
		561733 CL3L1_HUMAN (1-92): 1.09e-36: 120: 74.19		CCR5_HUMAN (6-355): 3.76e-72: 229: 54.55
+	Hs
		849619 CCL13_HUMAN (1-92): 3.42e-36: 119: 43.01		CCR3_HUMAN (1-355): 3.49e-72: 230: 58.03
+	Hs
		849654 CCL13_HUMAN (1-92): 3.42e-36: 119: 43.01		CCR5_HUMAN (6-355): 3.76e-72: 229: 54.55
+	Hs
		526564 CCL4_HUMAN (1-91): 1.49e-35: 117: 60.87		CCR3_HUMAN (1-355): 3.49e-72: 230: 58.03
+	Hs
		526565 CCL4_HUMAN (1-91): 1.49e-35: 117: 60.87		CCR5_HUMAN (6-355): 3.76e-72: 229: 54.55
+	Hs
		849616 CCL14_HUMAN (1-91): 1.84e-34: 115: 45.16		CCR3_HUMAN (1-355): 3.49e-72: 230: 58.03
+	Hs
		134400 CCL13_HUMAN (1-92): 3.42e-36: 119: 43.01		ACKR2_HUMAN (16-313): 4.77e-53: 181: 39.74
+	Hs
		134356 CCL4_HUMAN (1-91): 1.49e-35: 117: 60.87		ACKR2_HUMAN (16-313): 4.77e-53: 181: 39.74
+	Hs
		134380 CCL14_HUMAN (1-91): 1.84e-34: 115: 45.16		ACKR2_HUMAN (16-313): 4.77e-53: 181: 39.74
+	Hs
		134354 CCL3_HUMAN (1-92): 1.09e-33: 113: 74.19		ACKR2_HUMAN (16-313): 4.77e-53: 181: 39.74
+	Hs
		526561 CCL4_HUMAN (1-91): 1.49e-35: 117: 60.87		CXCR5_HUMAN (31-318): 4.65e-46: 162: 32.65
+	Hs
		830629 CCL13_HUMAN (1-92): 3.42e-36: 119: 43.01		CXCR3_HUMAN (13-315): 4.66e-44: 157: 32.92