HitPredict

Interactor 1: CXCL2 (P10889)
C-X-C motif chemokine 2 (Macrophage inflammatory protein 2) (MIP2)
Gene: CXCL2

Interactor 2: CXCR2 (P35343)
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (CD antigen CD182)
Gene: CXCR2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	7636264
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0007204 - positive regulation of cytosolic calcium ion concentration GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 100 Mm			1 359
+	Mm
		522397 GROA_MOUSE (26-96): 5.83e-27: 96.6: 69.01		CXCR2_MOUSE (1-348): 4.87e-83: 258: 100.00
+	Hs
		587767 CXCL2_HUMAN (22-100): 2.38e-28: 100: 63.29		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		364105 CXL10_HUMAN (10-95): 4.28e-22: 84.3: 26.14		CXCR3_HUMAN (68-356): 1.67e-78: 247: 38.83
+	Hs
		364080 PLF4_HUMAN (33-96): 1.21e-21: 83.2: 50.00		CXCR3_HUMAN (68-356): 1.67e-78: 247: 38.83
+	Hs
		150317 CXL11_HUMAN (14-97): 1.29e-21: 82.8: 26.74		CXCR3_HUMAN (68-356): 1.67e-78: 247: 38.83
+	Hs
		364042 CXCL7_HUMAN (30-99): 8.53e-27: 97: 54.29		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		625748 CXCL5_HUMAN (20-97): 4.96e-27: 97: 47.44		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		448988 GROA_HUMAN (30-100): 1.73e-26: 95.5: 66.20		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		587786 CXCL3_HUMAN (30-100): 3.51e-26: 94.7: 69.01		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		625758 CXCL6_HUMAN (23-97): 9.47e-25: 91.2: 50.67		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		486185 IL8_HUMAN (31-100): 4.63e-23: 86.6: 43.66		CXCR2_HUMAN (1-359): 7.34e-73: 232: 70.83
+	Hs
		364041 CXCL7_HUMAN (30-99): 8.53e-27: 97: 54.29		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Hs
		625736 CXCL5_HUMAN (20-97): 4.96e-27: 97: 47.44		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Hs
		448987 GROA_HUMAN (30-100): 1.73e-26: 95.5: 66.20		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Hs
		625737 CXCL6_HUMAN (23-97): 9.47e-25: 91.2: 50.67		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Hs
		486184 IL8_HUMAN (31-100): 4.63e-23: 86.6: 43.66		CXCR1_HUMAN (10-346): 1.74e-67: 217: 69.44
+	Mm
		291525 CXCL9_MOUSE (8-92): 4.57e-26: 95.1: 34.48		CXCR3_MOUSE (68-332): 2.68e-55: 186: 39.63
+	Mm
		291524 CXL10_MOUSE (10-96): 2.6e-24: 89.7: 28.09		CXCR3_MOUSE (68-332): 2.68e-55: 186: 39.63
+	Hs
		364107 CXL10_HUMAN (10-95): 4.28e-22: 84.3: 26.14		CCR3_HUMAN (53-324): 6.24e-38: 140: 33.70
+	Hs
		150319 CXL11_HUMAN (14-97): 1.29e-21: 82.8: 26.74		CCR3_HUMAN (53-324): 6.24e-38: 140: 33.70