HitPredict

Interactor 1: CLUS (P10909)
Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)]
Gene: CLU

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010628 - positive regulation of gene expression
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 449 Hs			1 839
+	Hs
		500700 CLUS_HUMAN (1-449): 0: 697: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		434122 CLUS_HUMAN (1-449): 0: 697: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		500801 CLUS_HUMAN (1-449): 0: 697: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		500782 CLUS_HUMAN (1-449): 0: 697: 100.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		435508 CLUS_HUMAN (1-449): 0: 697: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Rn
		102526 G3V836_RAT (14-449): 0: 688: 75.90		INSR_RAT (513-824): 3.31e-62: 230: 38.80