HitPredict

Interactor 1: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0042169 - SH2 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 304
+	Hs
		500944 GHR_HUMAN (1-638): 0: 731: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		500956 GHR_HUMAN (1-638): 0: 731: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		500941 GHR_HUMAN (1-638): 0: 731: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		548629 PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		560471 PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		645941 CNTFR_HUMAN (2-260): 9.56e-52: 184: 18.49		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		581156 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		548635 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		562545 IL7RA_HUMAN (127-483): 2.97e-70: 236: 21.82		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		540269 EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86		PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43
+	Mm
		540274 EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86		PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40
+	Mm
		540268 EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		580917 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562621 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		581157 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		645942 CNTFR_HUMAN (2-260): 9.56e-52: 184: 18.49		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		581163 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		GRAP_HUMAN (135-294): 3.79e-21: 91.4: 16.67
+	Hs
		924809 CSF3R_HUMAN (28-468): 1.54e-42: 166: 11.62		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		682260 IL2RG_HUMAN (27-352): 1.72e-44: 164: 13.99		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		557612 CNTFR_HUMAN (2-260): 9.56e-52: 184: 18.49		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00