HitPredict

Interactor 1: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 780
+	Hs
		441167 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		500978 GHR_HUMAN (1-638): 0: 731: 100.00		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Hs
		500946 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Mm
		562609 GHR_MOUSE (1-637): 0: 748: 67.85		PTN11_MOUSE (7-351): 2.04e-124: 387: 31.48
+	Hs
		500943 GHR_HUMAN (1-638): 0: 731: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		500960 GHR_HUMAN (1-638): 0: 731: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		500952 GHR_HUMAN (1-638): 0: 731: 100.00		PTN9_HUMAN (3-306): 5.55e-124: 385: 31.98
+	Hs
		500942 GHR_HUMAN (1-638): 0: 731: 100.00		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		500966 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		500973 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRH_HUMAN (57-299): 1.91e-46: 181: 40.08
+	Hs
		500961 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		560475 PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		441174 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		581148 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		581151 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		573561 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		581161 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		265768 CRLF1_HUMAN (8-257): 1.99e-55: 195: 19.62		PTPRS_HUMAN (8-299): 1.74e-91: 316: 31.65
+	Hs
		581149 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		581162 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13