HitPredict

Interactor 1: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.865

The method score is based on:

Property Details
Experiments 9442080, 10976913, 9632636
Identification Methods pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~fn3
Common GO terms GO:0005829 - cytosol
GO:0009755 - hormone-mediated signaling pathway
GO:0019221 - cytokine-mediated signaling pathway
GO:0019901 - protein kinase binding
GO:0042445 - hormone metabolic process
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 638
Hs

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Last updated: 15 Jul 2024