HitPredict

Interactor 1: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 807
+	Hs
		500959 GHR_HUMAN (1-638): 0: 731: 100.00		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Hs
		500942 GHR_HUMAN (1-638): 0: 731: 100.00		PTN2_HUMAN (26-399): 3.73e-129: 393: 28.76
+	Hs
		500946 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRB_HUMAN (18-314): 2.09e-117: 393: 31.19
+	Hs
		500952 GHR_HUMAN (1-638): 0: 731: 100.00		PTN9_HUMAN (7-301): 8.62e-119: 372: 31.61
+	Hs
		500966 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRK_HUMAN (20-292): 9.08e-61: 225: 30.96
+	Hs
		500961 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10
+	Hs
		500973 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRH_HUMAN (19-300): 4.95e-45: 177: 36.82
+	Mm
		562609 GHR_MOUSE (1-637): 0: 748: 67.85		PTN11_MOUSE (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		500960 GHR_HUMAN (1-638): 0: 731: 100.00		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		441167 GHR_HUMAN (1-638): 0: 731: 100.00		PTPRC_HUMAN (61-462): 5.14e-11: 68.6: 9.24
+	Hs
		581151 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		665815 LIFR_HUMAN (9-377): 2.99e-43: 169: 12.27		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		581148 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRB_HUMAN (18-314): 2.09e-117: 393: 31.19
+	Hs
		265768 CRLF1_HUMAN (8-257): 1.99e-55: 195: 19.62		PTPRS_HUMAN (13-292): 1.12e-105: 359: 35.66
+	Hs
		560475 PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		581149 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRG_HUMAN (30-294): 3.35e-51: 196: 25.54
+	Hs
		581162 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10
+	Hs
		581167 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRO_HUMAN (45-299): 3.56e-43: 171: 38.22
+	Hs
		581161 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		441174 EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84		PTPRC_HUMAN (61-462): 5.14e-11: 68.6: 9.24