HitPredict

Interactor 1: IRF1 (P10914)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Interactor 2: TNF10 (P50591)
Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Gene: TNFSF10

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	17617740, 15241475
Identification Methods	anti tag coimmunoprecipitation, electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 325 Hs			1 281
+	Hs
		536494 IRF2_HUMAN (1-268): 2.01e-86: 265: 45.55		TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00
+	Hs
		352458 IRF1_HUMAN (1-325): 2.66e-166: 467: 100.00		TNFA_HUMAN (94-280): 1.57e-50: 167: 19.07
+	Mm
		420386 IRF1_MOUSE (1-325): 2.47e-161: 455: 84.50		TNFA_MOUSE (121-280): 2.42e-52: 172: 19.64
+	Hs
		841072 IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29		TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00
+	Hs
		841070 IRF5_HUMAN (2-297): 2.67e-54: 186: 24.05		TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00
+	Mm
		420389 IRF8_MOUSE (7-270): 2.81e-94: 287: 28.03		TNFA_MOUSE (121-280): 2.42e-52: 172: 19.64
+	Hs
		352614 IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29		TNFA_HUMAN (94-280): 1.57e-50: 167: 19.07