HitPredict

Interactor 1: IRF1 (P10914)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Interactor 2: IFNL1 (Q8IU54)
Interferon lambda-1 (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29)
Gene: IFNL1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17785777, 21398614
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008285 - negative regulation of cell population proliferation GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0051607 - defense response to virus
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 325 Hs			1 200
+	Hs
		501067 IRF1_HUMAN (1-325): 2.66e-166: 467: 100.00		IFNL3_HUMAN (1-191): 5.14e-117: 331: 71.94
+	Hs
		971740 IRF8_HUMAN (7-270): 1.22e-99: 301: 28.79		IFNL1_HUMAN (1-200): 1.33e-123: 348: 100.00
+	Hs
		971741 IRF8_HUMAN (7-270): 1.22e-99: 301: 28.79		IFNL3_HUMAN (1-191): 5.14e-117: 331: 71.94
+	Hs
		1056433 IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29		IFNL1_HUMAN (1-200): 1.33e-123: 348: 100.00
+	Hs
		1056436 IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29		IFNL3_HUMAN (1-191): 5.14e-117: 331: 71.94
+	Hs
		1215834 IRF7_HUMAN (4-252): 9.35e-41: 150: 21.09		IFNL1_HUMAN (1-200): 1.33e-123: 348: 100.00
+	Hs
		1224458 IRF7_HUMAN (4-252): 9.35e-41: 150: 21.09		IFNL3_HUMAN (1-191): 5.14e-117: 331: 71.94