HitPredict

Interactor 1: MLRV (P10916)
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
Gene: MYL2

Interactor 2: MYH1 (P12882)
Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)
Gene: MYH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head, EF-hand_7~Myosin_N
Common GO terms	GO:0005737 - cytoplasm GO:0031672 - A band
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 166 Hs			1 1939
+	Mm
		1143166 Q6ZWQ9_MOUSE (1-165): 1.13e-64: 197: 54.12		MYH10_MOUSE (957-1938): 8.59e-61: 233: 17.99
+	Dm
		773034 SQH_DROME (6-165): 1.03e-60: 187: 53.75		MYSN_DROME (860-1938): 3.08e-58: 225: 16.91
+	Hs
		159635 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYH15_HUMAN (929-1939): 1.76e-56: 219: 16.57
+	Hs
		159551 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYH11_HUMAN (717-1757): 5.61e-56: 218: 15.64
+	Hs
		580616 ML12A_HUMAN (10-165): 6.39e-50: 159: 56.41		MYH11_HUMAN (717-1757): 5.61e-56: 218: 15.64
+	Hs
		159550 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYH10_HUMAN (1083-1938): 2.16e-54: 212: 15.35
+	Hs
		159549 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYH9_HUMAN (1104-1938): 6.77e-54: 211: 16.02
+	Hs
		624342 MYL9_HUMAN (10-165): 2.5e-50: 161: 55.77		MYH10_HUMAN (1083-1938): 2.16e-54: 212: 15.35
+	Hs
		624341 MYL9_HUMAN (10-165): 2.5e-50: 161: 55.77		MYH9_HUMAN (1104-1938): 6.77e-54: 211: 16.02
+	Hs
		580615 ML12A_HUMAN (10-165): 6.39e-50: 159: 56.41		MYH10_HUMAN (1083-1938): 2.16e-54: 212: 15.35
+	Hs
		580614 ML12A_HUMAN (10-165): 6.39e-50: 159: 56.41		MYH9_HUMAN (1104-1938): 6.77e-54: 211: 16.02
+	Dm
		404219 MLR_DROME (5-160): 2.35e-29: 108: 38.99		MYSA_DROME (925-1939): 4.77e-59: 228: 16.86
+	Ce
		361122 MLR1_CAEEL (19-166): 9.27e-41: 136: 49.66		MYO1_CAEEL (726-1564): 2.62e-38: 160: 13.33
+	Ce
		361123 MLR2_CAEEL (19-166): 1.33e-40: 136: 49.66		MYO1_CAEEL (726-1564): 2.62e-38: 160: 13.33
+	Ce
		361111 MLR1_CAEEL (19-166): 9.27e-41: 136: 49.66		MYO4_CAEEL (723-1615): 2.18e-36: 154: 13.72
+	Ce
		361112 MLR2_CAEEL (19-166): 1.33e-40: 136: 49.66		MYO4_CAEEL (723-1615): 2.18e-36: 154: 13.72
+	Hs
		159595 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYH14_HUMAN (1418-1939): 4.82e-28: 126: 15.71
+	Hs
		580665 ML12A_HUMAN (10-165): 6.39e-50: 159: 56.41		MYH14_HUMAN (1418-1939): 4.82e-28: 126: 15.71
+	Hs
		648467 CALL3_HUMAN (10-89): 1.56e-09: 55.2: 21.69		MYH9_HUMAN (1104-1938): 6.77e-54: 211: 16.02