HitPredict

Interactor 1: MLRV (P10916)
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
Gene: MYL2

Interactor 2: MYL5 (Q02045)
Myosin light chain 5 (Myosin regulatory light chain 5) (Superfast myosin regulatory light chain 2) (MYLC2) (MyLC-2)
Gene: MYL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~EF-hand_7
Common GO terms	GO:0005509 - calcium ion binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008307 - structural constituent of muscle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 166 Hs			1 173
+	Hs
		159544 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYL9_HUMAN (16-173): 4.79e-70: 211: 53.80
+	Hs
		159539 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		ML12A_HUMAN (16-173): 8.75e-70: 210: 55.06
+	Hs
		580607 MYL9_HUMAN (10-165): 2.5e-50: 161: 55.77		ML12A_HUMAN (16-173): 8.75e-70: 210: 55.06
+	At
		989458 CDPK1_ARATH (56-164): 3.73e-12: 64.9: 12.84		CDPK1_ARATH (4-169): 1.12e-53: 181: 20.12
+	At
		1105900 CDPKB_ARATH (99-166): 4.52e-12: 64.9: 16.90		CDPKB_ARATH (4-169): 5.75e-53: 176: 20.71
+	At
		1104924 CDPK4_ARATH (99-166): 9.68e-12: 63.7: 17.65		CDPK4_ARATH (4-169): 5.6e-53: 177: 20.71
+	At
		188308 CML8_ARATH (86-165): 3.7e-12: 62.1: 13.75		CDPK3_ARATH (4-171): 6.6e-50: 169: 16.96
+	At
		483086 CALM4_ARATH (22-89): 4.45e-10: 56.8: 29.58		CDPK3_ARATH (4-171): 6.6e-50: 169: 16.96
+	At
		886549 CALM7_ARATH (22-89): 4.01e-10: 56.8: 29.58		CDPK3_ARATH (4-171): 6.6e-50: 169: 16.96
+	Hs
		484049 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		CALM3_HUMAN (99-173): 9.76e-17: 74.5: 18.67
+	At
		886540 CALM7_ARATH (22-89): 4.01e-10: 56.8: 29.58		CALM6_ARATH (100-173): 8.49e-17: 74.5: 20.27
+	At
		188361 CML8_ARATH (86-165): 3.7e-12: 62.1: 13.75		CDPKU_ARATH (89-173): 9.57e-12: 64.1: 28.24
+	At
		483177 CALM4_ARATH (22-89): 4.45e-10: 56.8: 29.58		CDPKU_ARATH (89-173): 9.57e-12: 64.1: 28.24
+	At
		886638 CALM7_ARATH (22-89): 4.01e-10: 56.8: 29.58		CDPKU_ARATH (89-173): 9.57e-12: 64.1: 28.24
+	Hs
		483903 CALM1_HUMAN (12-89): 1.76e-10: 57.9: 23.46		CALL3_HUMAN (28-95): 5.62e-10: 56.8: 21.13
+	Hs
		483976 CALM2_HUMAN (12-89): 1.76e-10: 57.9: 23.46		CALL3_HUMAN (28-95): 5.62e-10: 56.8: 21.13
+	Gm
		1196117 Q84P28_SOYBN (13-100): 2.4e-09: 56.8: 18.68		Q84P28_SOYBN (26-106): 5.16e-09: 56: 14.46