HitPredict

Interactor 1: MLRV (P10916)
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
Gene: MYL2

Interactor 2: ASPM (Q8IZT6)
Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)
Gene: ASPM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CH~EF-hand_7, EF-hand_7~IQ
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 3477
+	Hs
		483950 CALM1_HUMAN (12-89): 1.76e-10: 57.9: 23.46		ASPM_HUMAN (1-3477): 0: 2244: 100.00
+	Hs
		484022 CALM2_HUMAN (12-89): 1.76e-10: 57.9: 23.46		ASPM_HUMAN (1-3477): 0: 2244: 100.00
+	Hs
		484165 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		ASPM_HUMAN (1-3477): 0: 2244: 100.00
+	Dm
		574799 MLR_DROME (5-160): 2.35e-29: 108: 38.99		ACTN_DROME (936-1799): 6.36e-87: 309: 12.79
+	Ce
		183769 CALM_CAEEL (12-89): 1.98e-10: 57.5: 25.93		O17666_CAEEL (626-1138): 5.29e-92: 330: 19.17
+	Dm
		574809 CALM_DROME (12-89): 2.22e-10: 57.5: 25.93		ACTN_DROME (936-1799): 6.36e-87: 309: 12.79
+	Hs
		501118 MLRV_HUMAN (1-166): 6.09e-54: 169: 100.00		MYO5A_HUMAN (1780-2618): 8.03e-28: 126: 10.43
+	Hs
		501101 MLRV_HUMAN (1-166): 6.09e-54: 169: 100.00		MYH1_HUMAN (1679-2858): 2.39e-26: 122: 8.35
+	Hs
		159640 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYO5A_HUMAN (1780-2618): 8.03e-28: 126: 10.43
+	Hs
		501117 MLRV_HUMAN (1-166): 6.09e-54: 169: 100.00		MYO5B_HUMAN (1256-1945): 6.28e-14: 81.1: 13.87
+	Hs
		484206 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO5C_HUMAN (2658-3307): 6.45e-23: 110: 10.82
+	Dm
		51921 CALM_DROME (12-89): 2.22e-10: 57.5: 25.93		A1Z6Z9_DROME (1331-1972): 6.12e-20: 100: 12.17
+	Hs
		214479 CALM1_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO1B_HUMAN (1752-2123): 7.21e-15: 83.8: 16.24
+	Hs
		214480 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO1B_HUMAN (1752-2123): 7.21e-15: 83.8: 16.24
+	Hs
		484218 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO5B_HUMAN (1256-1945): 6.28e-14: 81.1: 13.87
+	Hs
		484107 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		SPTB2_HUMAN (2326-3469): 1.32e-10: 70.2: 8.55
+	Dm
		906697 CALM_DROME (12-89): 2.22e-10: 57.5: 25.93		MYO7A_DROME (1794-1995): 1.06e-09: 67.2: 17.33
+	Hs
		483925 CALM1_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO9B_HUMAN (1279-1443): 4.98e-09: 64.8: 25.30
+	Hs
		483999 CALM2_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO9B_HUMAN (1279-1443): 4.98e-09: 64.8: 25.30
+	Hs
		484117 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO9B_HUMAN (1279-1443): 4.98e-09: 64.8: 25.30