HitPredict

Interactor 1: MLRV (P10916)
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
Gene: MYL2

Interactor 2: MYO19 (Q96H55)
Unconventional myosin-XIX (Myosin head domain-containing protein 1)
Gene: MYO19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016459 - myosin complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 970
+	Hs
		1293042 MYL10_HUMAN (2-166): 1.98e-69: 211: 67.00		MYO19_HUMAN (1-970): 0: 1069: 100.00
+	Hs
		159609 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYO19_HUMAN (1-970): 0: 1069: 100.00
+	Hs
		580677 ML12A_HUMAN (10-165): 6.39e-50: 159: 56.41		MYO19_HUMAN (1-970): 0: 1069: 100.00
+	Mm
		1143166 Q6ZWQ9_MOUSE (1-165): 1.13e-64: 197: 54.12		MYH10_MOUSE (2-965): 0: 1000: 26.14
+	Hs
		501118 MLRV_HUMAN (1-166): 6.09e-54: 169: 100.00		MYO5A_HUMAN (10-937): 0: 1027: 29.21
+	Hs
		159640 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYO5A_HUMAN (10-937): 0: 1027: 29.21
+	Hs
		501117 MLRV_HUMAN (1-166): 6.09e-54: 169: 100.00		MYO5B_HUMAN (21-964): 0: 1002: 28.72
+	Hs
		159551 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYH11_HUMAN (2-965): 0: 1001: 26.34
+	Hs
		159550 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYH10_HUMAN (2-965): 0: 998: 26.14
+	Hs
		580616 ML12A_HUMAN (10-165): 6.39e-50: 159: 56.41		MYH11_HUMAN (2-965): 0: 1001: 26.34
+	Hs
		159549 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYH9_HUMAN (9-907): 0: 997: 28.63
+	Hs
		624342 MYL9_HUMAN (10-165): 2.5e-50: 161: 55.77		MYH10_HUMAN (2-965): 0: 998: 26.14
+	Hs
		624341 MYL9_HUMAN (10-165): 2.5e-50: 161: 55.77		MYH9_HUMAN (9-907): 0: 997: 28.63
+	Hs
		580615 ML12A_HUMAN (10-165): 6.39e-50: 159: 56.41		MYH10_HUMAN (2-965): 0: 998: 26.14
+	Hs
		580614 ML12A_HUMAN (10-165): 6.39e-50: 159: 56.41		MYH9_HUMAN (9-907): 0: 997: 28.63
+	Hs
		501101 MLRV_HUMAN (1-166): 6.09e-54: 169: 100.00		MYH1_HUMAN (12-802): 0: 980: 30.54
+	Hs
		159630 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYO6_HUMAN (50-677): 1.69e-119: 397: 36.01
+	Hs
		483966 CALM1_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO6_HUMAN (50-677): 1.69e-119: 397: 36.01
+	Hs
		484047 CALM2_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO6_HUMAN (50-677): 1.69e-119: 397: 36.01
+	Ss
		94703 F2Z5G3_PIG (12-89): 1.76e-10: 57.9: 23.46		MYO6_PIG (50-677): 1.83e-118: 394: 35.99