HitPredict

Interactor 1: MLRV (P10916)
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
Gene: MYL2

Interactor 2: MYO5B (Q9ULV0)
Unconventional myosin-Vb
Gene: MYO5B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~IQ, EF-hand_7~Myosin_head
Common GO terms	GO:0005737 - cytoplasm GO:0016459 - myosin complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 166 Hs			1 1848
+	Hs
		501118 MLRV_HUMAN (1-166): 6.09e-54: 169: 100.00		MYO5A_HUMAN (1-1848): 0: 1157: 61.96
+	Hs
		159640 ML12B_HUMAN (9-165): 7.04e-51: 162: 56.05		MYO5A_HUMAN (1-1848): 0: 1157: 61.96
+	Hs
		484218 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO5B_HUMAN (1-1848): 0: 1243: 100.00
+	Dm
		51921 CALM_DROME (12-89): 2.22e-10: 57.5: 25.93		A1Z6Z9_DROME (2-1842): 0: 921: 34.82
+	Dm
		906697 CALM_DROME (12-89): 2.22e-10: 57.5: 25.93		MYO7A_DROME (8-961): 0: 900: 34.48
+	Hs
		484202 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO10_HUMAN (5-1001): 0: 868: 30.59
+	Hs
		648611 CALL3_HUMAN (10-89): 1.56e-09: 55.2: 21.69		MYO10_HUMAN (5-1001): 0: 868: 30.59
+	Sp
		251969 CALM_SCHPO (22-89): 4.26e-10: 56.8: 25.35		MYO51_SCHPO (5-1098): 0: 856: 35.94
+	Sp
		293469 CALM_SCHPO (22-89): 4.26e-10: 56.8: 25.35		MYO52_SCHPO (6-949): 0: 683: 40.51
+	Hs
		484206 CALM3_HUMAN (12-89): 1.76e-10: 57.9: 23.46		MYO5C_HUMAN (848-1848): 5.22e-71: 266: 28.40
+	Hs
		501101 MLRV_HUMAN (1-166): 6.09e-54: 169: 100.00		MYH1_HUMAN (833-1487): 4.69e-26: 119: 13.90