HitPredict

Interactor 1: ACT (P10989)
Actin (EC 3.6.4.-)
Gene: act1

Interactor 2: COFI (P78929)
Cofilin (Actin-depolymerizing factor 1)
Gene: cof1

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	21148484, 21723825, 28282023, 22024167
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0030479 - actin cortical patch GO:0032153 - cell division site GO:0051286 - cell tip
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Sp			1 137
+	At
		477715 ACT1_ARATH (3-375): 0: 701: 87.94		ADF4_ARATH (2-135): 3.3e-55: 170: 38.97
+	At
		477714 ACT1_ARATH (3-375): 0: 701: 87.94		ADF6_ARATH (2-135): 1.56e-53: 167: 44.85
+	At
		477717 ACT3_ARATH (3-375): 0: 701: 87.94		ADF6_ARATH (2-135): 1.56e-53: 167: 44.85
+	Hs
		891649 ACTB_HUMAN (1-375): 0: 598: 90.40		DEST_HUMAN (3-134): 4.28e-47: 151: 33.78
+	Hs
		894652 ACTG_HUMAN (1-375): 0: 598: 91.47		DEST_HUMAN (3-134): 4.28e-47: 151: 33.78
+	Hs
		894665 Q1KLZ0_HUMAN (1-375): 0: 598: 90.40		DEST_HUMAN (3-134): 4.28e-47: 151: 33.78
+	Hs
		618038 ACTB_HUMAN (1-375): 0: 598: 90.40		COF1_HUMAN (3-134): 1.17e-45: 147: 33.55
+	Hs
		618049 ACTG_HUMAN (1-375): 0: 598: 91.47		COF1_HUMAN (3-134): 1.17e-45: 147: 33.55
+	Hs
		618096 Q1KLZ0_HUMAN (1-375): 0: 598: 90.40		COF1_HUMAN (3-134): 1.17e-45: 147: 33.55
+	Hs
		1092828 Q1KLZ0_HUMAN (1-375): 0: 598: 90.40		Q549N0_HUMAN (3-134): 4.23e-45: 146: 32.24
+	Hs
		891817 ACTB_HUMAN (1-375): 0: 598: 90.40		Q549N0_HUMAN (3-134): 4.23e-45: 146: 32.24
+	Hs
		892124 ACTB_HUMAN (1-375): 0: 598: 90.40		COF2_HUMAN (3-134): 4.23e-45: 146: 32.24
+	Hs
		929891 ACTG_HUMAN (1-375): 0: 598: 91.47		Q549N0_HUMAN (3-134): 4.23e-45: 146: 32.24
+	Hs
		930059 ACTG_HUMAN (1-375): 0: 598: 91.47		COF2_HUMAN (3-134): 4.23e-45: 146: 32.24
+	Hs
		891650 ACTB_HUMAN (1-375): 0: 598: 90.40		GMFB_HUMAN (8-134): 1.12e-36: 123: 19.70
+	Hs
		894697 ACTG_HUMAN (1-375): 0: 598: 91.47		GMFB_HUMAN (8-134): 1.12e-36: 123: 19.70
+	Hs
		891834 ACTB_HUMAN (1-375): 0: 598: 90.40		TWF2_HUMAN (10-137): 2.63e-18: 80.8: 23.13
+	Hs
		929897 ACTG_HUMAN (1-375): 0: 598: 91.47		TWF2_HUMAN (10-137): 2.63e-18: 80.8: 23.13
+	Hs
		891728 ACTB_HUMAN (1-375): 0: 598: 90.40		TWF1_HUMAN (8-137): 8.55e-18: 79.6: 21.32
+	Hs
		929835 ACTG_HUMAN (1-375): 0: 598: 91.47		TWF1_HUMAN (8-137): 8.55e-18: 79.6: 21.32