HitPredict

Interactor 1: ACT (P10989)
Actin (EC 3.6.4.-)
Gene: act1

Interactor 2: MYO2 (Q9USI6)
Myosin type-2 heavy chain 1 (Myosin type II heavy chain 1)
Gene: MYO2

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28808035
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Actin~Myosin_head
Common GO terms	GO:0005524 - ATP binding GO:0032153 - cell division site GO:0120104 - mitotic actomyosin contractile ring, proximal layer GO:0120105 - mitotic actomyosin contractile ring, intermediate layer GO:0120106 - mitotic actomyosin contractile ring, distal actin filament layer
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 375 Sp			1 1526
+	Sc
		446210 ACT_YEAST (1-375): 0: 588: 89.60		MYO1_YEAST (67-1521): 0: 694: 35.35
+	Dm
		404232 ACT6_DROME (2-375): 0: 590: 89.31		MYSA_DROME (19-1490): 0: 651: 33.61
+	Dm
		361160 ACT4_DROME (2-375): 0: 586: 88.77		MYSA_DROME (19-1490): 0: 651: 33.61
+	Rn
		892228 ACTB_RAT (1-375): 0: 598: 90.40		MYH9_RAT (1266-1526): 1.2e-15: 85.4: 14.18
+	Mm
		892205 ACTB_MOUSE (1-375): 0: 598: 90.40		MYH9_MOUSE (1266-1526): 2.58e-15: 84.2: 14.18
+	Hs
		724738 ACTB_HUMAN (1-375): 0: 598: 90.40		MYH9_HUMAN (1266-1526): 3.6e-15: 83.9: 14.18
+	Hs
		724762 ACTG_HUMAN (1-375): 0: 598: 91.47		MYH9_HUMAN (1266-1526): 3.6e-15: 83.9: 14.18
+	Rn
		892236 ACTB_RAT (1-375): 0: 598: 90.40		MYH10_RAT (1264-1526): 4.85e-15: 83.2: 13.69
+	Hs
		724766 ACTC_HUMAN (2-375): 0: 588: 89.04		MYH9_HUMAN (1266-1526): 3.6e-15: 83.9: 14.18
+	Hs
		724767 ACTS_HUMAN (2-375): 0: 588: 89.04		MYH9_HUMAN (1266-1526): 3.6e-15: 83.9: 14.18
+	Hs
		725136 ACTC_HUMAN (2-375): 0: 588: 89.04		MYH10_HUMAN (1264-1526): 2.45e-14: 80.9: 13.69
+	Hs
		725135 ACTH_HUMAN (2-375): 0: 586: 89.04		MYH10_HUMAN (1264-1526): 2.45e-14: 80.9: 13.69