HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.84 0.60 0.712

The method score is based on:

Property Details
Experiments 26496610, 30021884, 33957083, 37071682, 34349018
Identification Methods affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005509 - calcium ion binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
and 16 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 654
Hs

1 803
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Ce
+ Sc

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Last updated: 15 Jul 2024