HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: TNR1B (P20333)
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]
Gene: TNFRSF1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 461
+	Hs
		591270 HS71L_HUMAN (24-647): 0: 922: 63.16		TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00
+	Hs
		503419 HSP7C_HUMAN (26-637): 0: 916: 66.02		TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00
+	Hs
		564001 HSP76_HUMAN (25-635): 0: 915: 62.54		TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00
+	Hs
		313612 BIP_HUMAN (19-654): 0: 914: 100.00		TNF6B_HUMAN (47-277): 2.64e-44: 158: 29.96
+	Hs
		584330 HS71L_HUMAN (24-647): 0: 922: 63.16		TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36
+	Hs
		503470 HSP7C_HUMAN (26-637): 0: 916: 66.02		TNR5_HUMAN (29-267): 7.76e-40: 146: 26.12
+	Hs
		501703 BIP_HUMAN (19-654): 0: 914: 100.00		TNR6_HUMAN (44-320): 6.35e-39: 145: 15.77
+	Hs
		503413 HSP7C_HUMAN (26-637): 0: 916: 66.02		TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36
+	Hs
		563998 HSP76_HUMAN (25-635): 0: 915: 62.54		TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36
+	Hs
		501662 BIP_HUMAN (19-654): 0: 914: 100.00		TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36
+	Hs
		502732 BIP_HUMAN (19-654): 0: 914: 100.00		TNR18_HUMAN (92-224): 1.58e-27: 111: 23.36
+	Hs
		502805 HSP7C_HUMAN (26-637): 0: 916: 66.02		LAMC1_HUMAN (31-256): 1.09e-10: 66.1: 12.77
+	Hs
		501606 BIP_HUMAN (19-654): 0: 914: 100.00		LAMC1_HUMAN (31-256): 1.09e-10: 66.1: 12.77
+	Hs
		501701 BIP_HUMAN (19-654): 0: 914: 100.00		LAMA1_HUMAN (24-214): 3.19e-10: 64.9: 14.46