HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: GRAH (P20718)
Granzyme H (EC 3.4.21.-) (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C)
Gene: GZMH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 246
+	Hs
		428660 BIP_HUMAN (19-654): 0: 914: 100.00		TRY1_HUMAN (1-244): 1.57e-112: 324: 33.87
+	Hs
		428712 BIP_HUMAN (19-654): 0: 914: 100.00		TRY2_HUMAN (1-244): 5.94e-106: 308: 31.87
+	Hs
		439315 BIP_HUMAN (19-654): 0: 914: 100.00		CATG_HUMAN (1-246): 7.55e-101: 295: 57.32
+	Hs
		501693 BIP_HUMAN (19-654): 0: 914: 100.00		CMA1_HUMAN (13-244): 2.01e-92: 273: 47.86
+	Hs
		501667 BIP_HUMAN (19-654): 0: 914: 100.00		TRYB2_HUMAN (14-240): 2.8e-91: 271: 29.76
+	Hs
		420734 BIP_HUMAN (19-654): 0: 914: 100.00		KLK1_HUMAN (1-245): 4.51e-91: 270: 31.96
+	Mm
		371552 BIP_MOUSE (1-654): 0: 917: 98.62		CFAD_MOUSE (21-240): 6.77e-43: 147: 34.78
+	Mm
		371752 HSP7C_MOUSE (26-637): 0: 916: 66.02		CFAD_MOUSE (21-240): 6.77e-43: 147: 34.78
+	Hs
		501694 BIP_HUMAN (19-654): 0: 914: 100.00		PRTN3_HUMAN (20-246): 6.37e-41: 142: 37.45