HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: ROA2 (P22626)
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
Gene: HNRNPA2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24189400
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 353
+	Hs
		161945 BIP_HUMAN (19-654): 0: 914: 100.00		HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45
+	Hs
		609729 HS71L_HUMAN (24-647): 0: 922: 63.16		ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00
+	Hs
		609901 Q53FA3_HUMAN (24-647): 0: 922: 63.00		ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00
+	Hs
		503440 HSP7C_HUMAN (26-637): 0: 916: 66.02		ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00
+	Hs
		483748 HS71A_HUMAN (26-635): 0: 911: 64.11		ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00
+	Hs
		504019 HSP7C_HUMAN (26-637): 0: 916: 66.02		PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67
+	Hs
		502053 BIP_HUMAN (19-654): 0: 914: 100.00		PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67
+	Hs
		503332 HSP7C_HUMAN (26-637): 0: 916: 66.02		PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95
+	Hs
		504060 HSP7C_HUMAN (26-637): 0: 916: 66.02		HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77
+	Hs
		564075 HSP76_HUMAN (25-635): 0: 915: 62.54		HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77
+	Hs
		502086 BIP_HUMAN (19-654): 0: 914: 100.00		HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77
+	Hs
		503724 HSP7C_HUMAN (26-637): 0: 916: 66.02		ROA3_HUMAN (3-103): 2.78e-17: 84: 33.66
+	Hs
		501856 BIP_HUMAN (19-654): 0: 914: 100.00		ROA3_HUMAN (3-103): 2.78e-17: 84: 33.66
+	Hs
		453103 HSP7C_HUMAN (26-637): 0: 916: 66.02		ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92
+	Hs
		453102 BIP_HUMAN (19-654): 0: 914: 100.00		ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92
+	Hs
		502169 BIP_HUMAN (19-654): 0: 914: 100.00		RA1L2_HUMAN (3-96): 1.58e-15: 78.2: 31.92
+	Hs
		453234 HSP72_HUMAN (25-636): 0: 905: 64.51		ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92