HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: GRN (P28799)
Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
Gene: GRN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26370502
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane GO:0016020 - membrane GO:0030335 - positive regulation of cell migration GO:0051087 - protein-folding chaperone binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 593
+	Hs
		503497 HSP7C_HUMAN (26-637): 0: 916: 66.02		GRN_HUMAN (1-593): 0: 726: 100.00
+	Mm
		588737 BIP_MOUSE (1-654): 0: 917: 98.62		Q9D2V3_MOUSE (1-593): 0: 712: 75.04
+	Mm
		926160 HSP7C_MOUSE (26-637): 0: 916: 66.02		Q9D2V3_MOUSE (1-593): 0: 712: 75.04
+	Mm
		1143062 HS71A_MOUSE (26-635): 0: 908: 63.46		Q9D2V3_MOUSE (1-593): 0: 712: 75.04