HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: EPHA8 (P29322)
Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)
Gene: EPHA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 1005
+	Hs
		502130 BIP_HUMAN (19-654): 0: 914: 100.00		EPHA7_HUMAN (5-1005): 0: 1236: 56.16
+	Hs
		503499 HSP7C_HUMAN (26-637): 0: 916: 66.02		EPHB2_HUMAN (31-1005): 0: 1211: 49.95
+	Hs
		501728 BIP_HUMAN (19-654): 0: 914: 100.00		EPHB2_HUMAN (31-1005): 0: 1211: 49.95
+	Hs
		503517 HSP7C_HUMAN (26-637): 0: 916: 66.02		UFO_HUMAN (264-981): 3.57e-161: 499: 22.34
+	Hs
		564014 HSP76_HUMAN (25-635): 0: 915: 62.54		UFO_HUMAN (264-981): 3.57e-161: 499: 22.34
+	Hs
		502009 BIP_HUMAN (19-654): 0: 914: 100.00		TYRO3_HUMAN (264-987): 2.51e-149: 468: 21.12
+	Hs
		411284 BIP_HUMAN (19-654): 0: 914: 100.00		INSR_HUMAN (377-935): 6.29e-143: 463: 25.85
+	Hs
		411965 HSP7C_HUMAN (26-637): 0: 916: 66.02		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76
+	Hs
		411963 BIP_HUMAN (19-654): 0: 914: 100.00		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76