HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0030335 - positive regulation of cell migration
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 1055
+	Hs
		503499 HSP7C_HUMAN (26-637): 0: 916: 66.02		EPHB2_HUMAN (20-1055): 0: 1304: 100.00
+	Hs
		502130 BIP_HUMAN (19-654): 0: 914: 100.00		EPHA7_HUMAN (6-982): 0: 1154: 57.46
+	Hs
		501727 BIP_HUMAN (19-654): 0: 914: 100.00		EPHA8_HUMAN (20-982): 0: 1066: 50.71
+	Hs
		411284 BIP_HUMAN (19-654): 0: 914: 100.00		INSR_HUMAN (277-941): 5.94e-150: 484: 24.02
+	Hs
		503517 HSP7C_HUMAN (26-637): 0: 916: 66.02		UFO_HUMAN (266-950): 2.71e-152: 477: 23.12
+	Hs
		564014 HSP76_HUMAN (25-635): 0: 915: 62.54		UFO_HUMAN (266-950): 2.71e-152: 477: 23.12
+	Hs
		435511 HSP7C_HUMAN (26-637): 0: 916: 66.02		IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31
+	Rn
		419257 BIP_RAT (1-654): 0: 918: 98.47		INSR_RAT (280-937): 2.81e-145: 471: 24.56
+	Hs
		435510 BIP_HUMAN (19-654): 0: 914: 100.00		IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31
+	Rn
		544811 HSP7C_RAT (26-637): 0: 916: 66.02		INSR_RAT (280-937): 2.81e-145: 471: 24.56
+	Hs
		433227 HSP7C_HUMAN (26-637): 0: 916: 66.02		YES_HUMAN (572-881): 5.77e-65: 231: 42.95
+	Hs
		442767 HSP7C_HUMAN (26-637): 0: 916: 66.02		HCK_HUMAN (575-881): 7.23e-65: 230: 40.91
+	Hs
		442775 HSP76_HUMAN (25-635): 0: 915: 62.54		HCK_HUMAN (575-881): 7.23e-65: 230: 40.91
+	Hs
		442766 BIP_HUMAN (19-654): 0: 914: 100.00		HCK_HUMAN (575-881): 7.23e-65: 230: 40.91