HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: STIP1 (P31948)
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
Gene: STIP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 33239621
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 543
+	At
		1338008 HS704_ARATH (28-650): 0: 928: 63.54		HSOP1_ARATH (3-543): 3.3e-98: 310: 41.96
+	Hs
		684439 HS71L_HUMAN (24-647): 0: 922: 63.16		STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00
+	Hs
		503534 HSP7C_HUMAN (26-637): 0: 916: 66.02		STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00
+	Hs
		564017 HSP76_HUMAN (25-635): 0: 915: 62.54		STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00
+	Hs
		483776 HS71B_HUMAN (26-635): 0: 911: 64.11		STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00
+	Hs
		564151 HSP76_HUMAN (25-635): 0: 915: 62.54		SGTB_HUMAN (213-348): 5.73e-32: 126: 31.39
+	Hs
		1120567 Q53FA3_HUMAN (24-647): 0: 922: 63.00		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		714055 HS71L_HUMAN (24-647): 0: 922: 63.16		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		504631 HSP7C_HUMAN (26-637): 0: 916: 66.02		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		564163 HSP76_HUMAN (25-635): 0: 915: 62.54		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		502467 BIP_HUMAN (19-654): 0: 914: 100.00		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		483768 HS71A_HUMAN (26-635): 0: 911: 64.11		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		483801 HS71B_HUMAN (26-635): 0: 911: 64.11		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		564188 HSP76_HUMAN (25-635): 0: 915: 62.54		RPAP3_HUMAN (2-141): 4.46e-20: 96.1: 27.14
+	Hs
		174578 HSP7C_HUMAN (26-637): 0: 916: 66.02		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Hs
		174577 BIP_HUMAN (19-654): 0: 914: 100.00		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Hs
		297027 HSP7C_HUMAN (26-637): 0: 916: 66.02		TOM70_HUMAN (207-543): 4.08e-13: 73.8: 11.00
+	Mm
		926144 HSP7C_MOUSE (26-637): 0: 916: 66.02		SGTA_MOUSE (202-327): 4.16e-10: 63.2: 33.33
+	Hs
		213468 HSP7C_HUMAN (26-637): 0: 916: 66.02		SGTA_HUMAN (202-327): 3.98e-09: 60.1: 32.54
+	Hs
		502038 BIP_HUMAN (19-654): 0: 914: 100.00		IFT88_HUMAN (4-150): 8.37e-09: 60.3: 12.93