HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: M3K8 (P41279)
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Gene: MAP3K8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 467
+	Dm
		669813 BIP_DROME (27-654): 0: 989: 82.86		AKT1_DROME (44-464): 1.84e-131: 395: 13.90
+	Hs
		713919 HS71L_HUMAN (24-647): 0: 922: 63.16		M3K8_HUMAN (1-467): 9.62e-140: 411: 100.00
+	Hs
		503599 HSP7C_HUMAN (26-637): 0: 916: 66.02		M3K8_HUMAN (1-467): 9.62e-140: 411: 100.00
+	Hs
		503922 HSP7C_HUMAN (26-637): 0: 916: 66.02		KPCE_HUMAN (49-463): 9.48e-132: 399: 16.03
+	Hs
		503528 HSP7C_HUMAN (26-637): 0: 916: 66.02		AKT1_HUMAN (49-466): 1.05e-133: 396: 16.17
+	Mm
		554943 Q9DC41_MOUSE (1-654): 0: 915: 98.32		KPCE_MOUSE (49-463): 8.23e-131: 397: 15.80
+	Hs
		564016 HSP76_HUMAN (25-635): 0: 915: 62.54		AKT1_HUMAN (49-466): 1.05e-133: 396: 16.17
+	Hs
		501740 BIP_HUMAN (19-654): 0: 914: 100.00		AKT1_HUMAN (49-466): 1.05e-133: 396: 16.17
+	Mm
		554912 HS71A_MOUSE (26-635): 0: 908: 63.46		KPCE_MOUSE (49-463): 8.23e-131: 397: 15.80
+	Hs
		1120576 Q53FC7_HUMAN (25-635): 0: 912: 62.05		Q5T853_HUMAN (1-223): 5.66e-125: 364: 100.00
+	Hs
		713953 HS71L_HUMAN (24-647): 0: 922: 63.16		STK4_HUMAN (116-419): 2.68e-103: 318: 25.89
+	Hs
		503996 HSP7C_HUMAN (26-637): 0: 916: 66.02		STK4_HUMAN (116-419): 2.68e-103: 318: 25.89
+	Hs
		564065 HSP76_HUMAN (25-635): 0: 915: 62.54		STK4_HUMAN (116-419): 2.68e-103: 318: 25.89
+	Hs
		502036 BIP_HUMAN (19-654): 0: 914: 100.00		STK4_HUMAN (116-419): 2.68e-103: 318: 25.89
+	Hs
		502632 BIP_HUMAN (19-654): 0: 914: 100.00		STK26_HUMAN (144-386): 6e-37: 142: 34.80
+	Hs
		714054 HS71L_HUMAN (24-647): 0: 922: 63.16		M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66
+	Hs
		504625 HSP7C_HUMAN (26-637): 0: 916: 66.02		M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66
+	Hs
		564159 HSP76_HUMAN (25-635): 0: 915: 62.54		M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66
+	Hs
		502464 BIP_HUMAN (19-654): 0: 914: 100.00		M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66
+	Hs
		483800 HS71B_HUMAN (26-635): 0: 911: 64.11		M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66