HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: LOXL3 (P58215)
Lysyl oxidase homolog 3 (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3)
Gene: LOXL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 753
+	Hs
		502714 BIP_HUMAN (19-654): 0: 914: 100.00		LOXL2_HUMAN (26-752): 0: 990: 56.19
+	Hs
		504582 HSP7C_HUMAN (26-637): 0: 916: 66.02		LOXL4_HUMAN (25-752): 0: 953: 54.96
+	Hs
		483799 HS71B_HUMAN (26-635): 0: 911: 64.11		LOXL4_HUMAN (25-752): 0: 953: 54.96
+	Hs
		871735 HSP72_HUMAN (25-636): 0: 905: 64.51		LOXL4_HUMAN (25-752): 0: 953: 54.96
+	Hs
		82341 BIP_HUMAN (19-654): 0: 914: 100.00		B9A025_HUMAN (1-429): 1.54e-114: 360: 54.34
+	Hs
		501725 BIP_HUMAN (19-654): 0: 914: 100.00		LYOX_HUMAN (525-729): 1.1e-100: 318: 51.21
+	Mm
		571847 HS71B_MOUSE (26-635): 0: 908: 63.46		LYOX_MOUSE (525-729): 1.09e-102: 323: 51.21
+	Hs
		483749 HS71A_HUMAN (26-635): 0: 911: 64.11		LYOX_HUMAN (525-729): 1.1e-100: 318: 51.21
+	Hs
		503966 HSP7C_HUMAN (26-637): 0: 916: 66.02		LG3BP_HUMAN (162-281): 1e-32: 136: 27.50
+	Hs
		502015 BIP_HUMAN (19-654): 0: 914: 100.00		LG3BP_HUMAN (162-281): 1e-32: 136: 27.50
+	Hs
		502436 BIP_HUMAN (19-654): 0: 914: 100.00		HIPL1_HUMAN (160-281): 1.53e-27: 120: 24.59