HitPredict

Interactor 1: MSCS (P0C0S1)
Small-conductance mechanosensitive channel
Gene: MSCS

Interactor 2: MSCS (P0C0S1)
Small-conductance mechanosensitive channel
Gene: MSCS

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	16079137, 26551077, 12446901, 18755969
Identification Methods	blue native page, molecular sieving, mass spectrometry studies of complexes, x-ray crystallography, comigration in non denaturing gel electrophoresis
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	MS_channel_1st~MS_channel_1st, MS_channel_1st~MS_channel_1st_1, MS_channel_1st~MS_channel_2nd, MS_channel_1st_1~MS_channel_1st_1, MS_channel_1st_1~MS_channel_2nd, MS_channel_2nd~MS_channel_2nd, MS_channel_2nd~MS_channel_3rd, MS_channel_3rd~MS_channel_3rd
Common GO terms	GO:0005886 - plasma membrane GO:0008381 - mechanosensitive monoatomic ion channel activity GO:0009992 - intracellular water homeostasis GO:0016020 - membrane GO:0034220 - monoatomic ion transmembrane transport and 1 others more... GO:0051260 - protein homooligomerization
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 286 Ec			1 286
+	Ec
		90674 C3SVH2_ECOLX (1-286): 7.13e-81: 247: 100.00		C3SVH2_ECOLX (1-286): 7.13e-81: 247: 100.00
+	Ec
		500106 YNAI_ECOLI (24-286): 9.5e-63: 202: 20.37		YNAI_ECOLI (24-286): 9.5e-63: 202: 20.37
+	Ec
		498016 YBDG_ECOLI (22-282): 4.65e-38: 140: 14.15		YBDG_ECOLI (22-282): 4.65e-38: 140: 14.15