HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 665
+	Hs
		504539 HSP7C_HUMAN (26-637): 0: 916: 66.02		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		505017 HSP7C_HUMAN (26-637): 0: 916: 66.02		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		713938 HS71L_HUMAN (24-647): 0: 922: 63.16		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		501645 BIP_HUMAN (19-654): 0: 914: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		503853 HSP7C_HUMAN (26-637): 0: 916: 66.02		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		501953 BIP_HUMAN (19-654): 0: 914: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Ce
		647814 HSP7C_CAEEL (28-654): 0: 949: 79.52		Q9U2T9_CAEEL (142-349): 4.59e-14: 78.1: 18.48
+	Ce
		450542 HSP1_CAEEL (30-637): 0: 906: 64.65		Q9U2T9_CAEEL (142-349): 4.59e-14: 78.1: 18.48