HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: DNJC7 (Q99615)
DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)
Gene: DNAJC7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0031072 - heat shock protein binding GO:0051085 - chaperone cofactor-dependent protein refolding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 494
+	Hs
		1120567 Q53FA3_HUMAN (24-647): 0: 922: 63.00		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		714055 HS71L_HUMAN (24-647): 0: 922: 63.16		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		504631 HSP7C_HUMAN (26-637): 0: 916: 66.02		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		174578 HSP7C_HUMAN (26-637): 0: 916: 66.02		OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59
+	Hs
		713956 HS71L_HUMAN (24-647): 0: 922: 63.16		DNJC3_HUMAN (14-289): 8.21e-26: 112: 17.83
+	Hs
		504014 HSP7C_HUMAN (26-637): 0: 916: 66.02		DNJC3_HUMAN (14-289): 8.21e-26: 112: 17.83
+	Hs
		684439 HS71L_HUMAN (24-647): 0: 922: 63.16		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		503534 HSP7C_HUMAN (26-637): 0: 916: 66.02		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		279280 HS71L_HUMAN (24-647): 0: 922: 63.16		DNJB5_HUMAN (380-491): 5.82e-19: 90.1: 43.31
+	Hs
		714088 HS71L_HUMAN (24-647): 0: 922: 63.16		DNJB4_HUMAN (380-479): 7.53e-18: 86.7: 45.22
+	Hs
		279272 HSP7C_HUMAN (26-637): 0: 916: 66.02		DNJB5_HUMAN (380-491): 5.82e-19: 90.1: 43.31
+	Hs
		279274 HSP76_HUMAN (25-635): 0: 915: 62.54		DNJB5_HUMAN (380-491): 5.82e-19: 90.1: 43.31
+	Hs
		504901 HSP7C_HUMAN (26-637): 0: 916: 66.02		DNJB4_HUMAN (380-479): 7.53e-18: 86.7: 45.22
+	At
		1338008 HS704_ARATH (28-650): 0: 928: 63.54		HSOP1_ARATH (148-446): 8.27e-13: 72.8: 16.33
+	Hs
		714022 HS71L_HUMAN (24-647): 0: 922: 63.16		DNJB8_HUMAN (381-482): 1.21e-15: 78.2: 44.35
+	Mm
		926131 HSP7C_MOUSE (26-637): 0: 916: 66.02		PPP5_MOUSE (139-260): 3.58e-16: 82.8: 13.93
+	Hs
		503512 HSP7C_HUMAN (26-637): 0: 916: 66.02		CDC27_HUMAN (4-128): 1.63e-15: 81.6: 20.80
+	Hs
		504474 HSP7C_HUMAN (26-637): 0: 916: 66.02		DNJB3_HUMAN (381-485): 1.24e-16: 78.6: 40.68
+	Hs
		504431 HSP7C_HUMAN (26-637): 0: 916: 66.02		DNJB8_HUMAN (381-482): 1.21e-15: 78.2: 44.35
+	Hs
		503738 HSP7C_HUMAN (26-637): 0: 916: 66.02		PPP5_HUMAN (242-391): 7.28e-09: 60.1: 31.79