HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: RSPO3 (Q9BXY4)
R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2)
Gene: RSPO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.50	0.470

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 272
+	Rn
		419257 BIP_RAT (1-654): 0: 918: 98.47		INSR_RAT (15-164): 1.28e-40: 151: 18.18
+	Rn
		544811 HSP7C_RAT (26-637): 0: 916: 66.02		INSR_RAT (15-164): 1.28e-40: 151: 18.18
+	Hs
		411284 BIP_HUMAN (19-654): 0: 914: 100.00		INSR_HUMAN (15-164): 5.18e-40: 149: 17.31
+	Hs
		435511 HSP7C_HUMAN (26-637): 0: 916: 66.02		IGF1R_HUMAN (15-176): 8.51e-34: 131: 16.27
+	Hs
		435510 BIP_HUMAN (19-654): 0: 914: 100.00		IGF1R_HUMAN (15-176): 8.51e-34: 131: 16.27