HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: DDX24 (Q9GZR7)
ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)
Gene: DDX24

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	16169070, 35864588
Identification Methods	two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane GO:0016887 - ATP hydrolysis activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 859
+	Hs
		504721 HSP7C_HUMAN (26-637): 0: 916: 66.02		DDX24_HUMAN (1-859): 8.65e-159: 487: 100.00
+	Hs
		133856 HSP7C_HUMAN (26-637): 0: 916: 66.02		DDX3X_HUMAN (158-723): 2.85e-123: 388: 19.08
+	Hs
		133855 BIP_HUMAN (19-654): 0: 914: 100.00		DDX3X_HUMAN (158-723): 2.85e-123: 388: 19.08
+	Hs
		503397 HSP7C_HUMAN (26-637): 0: 916: 66.02		DDX5_HUMAN (232-774): 1.14e-121: 382: 19.89
+	Hs
		501653 BIP_HUMAN (19-654): 0: 914: 100.00		DDX5_HUMAN (232-774): 1.14e-121: 382: 19.89
+	Sc
		415880 BIP_YEAST (22-638): 0: 798: 68.82		DED1_YEAST (255-734): 7.5e-120: 377: 23.74
+	Hs
		504840 HSP7C_HUMAN (26-637): 0: 916: 66.02		DDX18_HUMAN (391-740): 1.22e-32: 137: 29.69
+	Hs
		504735 HSP7C_HUMAN (26-637): 0: 916: 66.02		DDX47_HUMAN (177-261): 2.92e-12: 71.7: 36.47
+	Hs
		504506 HSP7C_HUMAN (26-637): 0: 916: 66.02		DDX17_HUMAN (130-267): 9.12e-12: 70.9: 21.43