HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: COPG2 (Q9UBF2)
Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)
Gene: COPG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	34349018, 35271311
Identification Methods	cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 871
+	Hs
		502735 BIP_HUMAN (19-654): 0: 914: 100.00		COPG1_HUMAN (1-871): 0: 844: 80.44
+	Rn
		88760 HSP7C_RAT (26-637): 0: 916: 66.02		D3ZUY8_RAT (24-871): 0: 578: 14.76
+	Hs
		321472 HSP7C_HUMAN (26-637): 0: 916: 66.02		AP2A1_HUMAN (24-871): 0: 567: 14.88
+	Hs
		503976 HSP7C_HUMAN (26-637): 0: 916: 66.02		AP1B1_HUMAN (14-638): 2.54e-177: 538: 14.84
+	Rn
		923849 HSP7C_RAT (26-637): 0: 916: 66.02		AP2B1_RAT (14-600): 2.1e-176: 535: 14.45
+	Hs
		212591 HSP7C_HUMAN (26-637): 0: 916: 66.02		AP1G1_HUMAN (20-738): 1.94e-170: 516: 15.07