HitPredict

Interactor 1: ARF1 (P11076)
ADP-ribosylation factor 1 (EC 3.6.5.2)
Gene: ARF1

Interactor 2: COPG (P32074)
Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP)
Gene: SEC21

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.786

Property	Details
Experiments	2105501, 22304919
Identification Methods	electron microscopy, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Adaptin_N~Arf
Common GO terms	GO:0006886 - intracellular protein transport GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Sc			1 935
+	Hs
		912839 ARF6_HUMAN (5-179): 5.38e-71: 214: 65.71		AP2B1_HUMAN (3-925): 0: 672: 15.12
+	Hs
		913157 ARF6_HUMAN (5-179): 5.38e-71: 214: 65.71		COPG2_HUMAN (7-933): 0: 666: 32.34
+	Hs
		912875 ARF6_HUMAN (5-179): 5.38e-71: 214: 65.71		AP1B1_HUMAN (3-926): 0: 661: 15.33
+	Hs
		950736 ARF5_HUMAN (1-180): 1.01e-68: 208: 69.44		COPG2_HUMAN (7-933): 0: 666: 32.34
+	Hs
		897411 ARF3_HUMAN (1-180): 7.11e-68: 206: 76.11		COPG2_HUMAN (7-933): 0: 666: 32.34
+	Hs
		913217 ARF6_HUMAN (5-179): 5.38e-71: 214: 65.71		COPG1_HUMAN (3-933): 0: 655: 31.71
+	Hs
		950481 ARF1_HUMAN (1-180): 2.46e-68: 207: 77.22		AP1B1_HUMAN (3-926): 0: 661: 15.33
+	Hs
		950752 ARF5_HUMAN (1-180): 1.01e-68: 208: 69.44		COPG1_HUMAN (3-933): 0: 655: 31.71
+	Hs
		950585 ARF1_HUMAN (1-180): 2.46e-68: 207: 77.22		COPG1_HUMAN (3-933): 0: 655: 31.71
+	Dm
		778364 ARF4_DROME (1-180): 4.46e-73: 219: 72.78		Q24253_DROME (3-932): 0: 634: 14.00
+	Dm
		897433 ARF1_DROME (1-181): 5.18e-68: 206: 78.45		Q24253_DROME (3-932): 0: 634: 14.00
+	Hs
		321520 ARF6_HUMAN (5-179): 5.38e-71: 214: 65.71		AP2A1_HUMAN (6-935): 0: 619: 11.75
+	Dm
		778370 ARF4_DROME (1-180): 4.46e-73: 219: 72.78		COPG_DROME (1-933): 0: 599: 30.91
+	Dm
		897447 ARF1_DROME (1-181): 5.18e-68: 206: 78.45		COPG_DROME (1-933): 0: 599: 30.91
+	Hs
		863193 ARF6_HUMAN (5-179): 5.38e-71: 214: 65.71		COPB_HUMAN (14-926): 2.26e-167: 515: 10.07
+	Hs
		863201 ARF5_HUMAN (1-180): 1.01e-68: 208: 69.44		COPB_HUMAN (14-926): 2.26e-167: 515: 10.07
+	Hs
		863200 ARF1_HUMAN (1-180): 2.46e-68: 207: 77.22		COPB_HUMAN (14-926): 2.26e-167: 515: 10.07
+	Hs
		863188 ARF3_HUMAN (1-180): 7.11e-68: 206: 76.11		COPB_HUMAN (14-926): 2.26e-167: 515: 10.07
+	Hs
		212615 ARF6_HUMAN (5-179): 5.38e-71: 214: 65.71		AP1G1_HUMAN (1-799): 1.23e-105: 348: 13.50
+	Hs
		212618 ARF1_HUMAN (1-180): 2.46e-68: 207: 77.22		AP1G1_HUMAN (1-799): 1.23e-105: 348: 13.50